Stand by for a big-six bottleneck! Between now and the next international break the games come thick and fast – with each side facing action in three competitions.
Liverpool, Chelsea and Watford sit proudly top of the Premier League table heading out of the first international break of the season, but by the time England and the other national sides reconvene in early October things are certain to have changed at the top.
With the main stages of the Champions League and Europa League both kicking off too, and the League Cup ramping up, there are plenty of other games to keep the bosses of the big six clubs on their toes.
Here, Sportsmail looks at the chaotic month ahead and examines which of the six superpowers has the toughest ride.
A blistering start and what appears to be an astute summer of business has them dreaming of a first Premier League title on the red half of Merseyside. It is safe to say we will have a good idea if that optimism is well-placed over the coming weeks.
In the league there are two tough trips to London to face Tottenham and Chelsea, while Manchester City will head to Anfield seeking revenge. Only the visit of Southampton is seen as a gimme.
It gets no better in the Champions League, with Napoli and Paris Saint-Germain on the horizon. Even the League Cup gets in on the act, with another date with Chelsea far from straightforward. Over to you, Jurgen.
Maximum points from the opening four matches means Maurizio Sarri is not the only one smoking at Stamford Bridge.
The Italian has enjoyed a fine start to his regime in west London but travel may well be the issue, rather than strength of opposition, over the coming weeks.
The Premier League throws up tussles with Cardiff City, West Ham United and Southampton, with Liverpool the only match which should not be viewed as a comfortable three points.
What damage long Europa League trips will do, however, remains to be seen.
Other than the trip to Liverpool on October 7, this is a relatively straightforward period of the season for Pep Guardiola and his crew.
Fulham, Cardiff and Brighton reads like a relegation prediction, while Oxford in the League Cup will give the Catalan the opportunity to get his fringe men and youngsters some game time.
There have been tougher Champions League opponents than Lyon and Hoffenheim, and City supporters will be confident their team can go to Liverpool in decent shape.
The nomads kick off with the visit of Liverpool to Wembley in what should have been the first match at their new stadium.
Brighton, Huddersfield and Cardiff should all yield three points, but daunting Champions League tussles with Inter Milan and Barcelona will test the strength and size of Mauricio Pochettino’s squad.
A trip to Milton Keynes in the League Cup to face Watford will also provide a stern challenge, most likely to Pochettino’s fringe members.
The way Unai Emery’s men celebrated victory at Cardiff City should give you an indication of the expectation levels at the Emirates this year.
Like Chelsea, travel could be their biggest enemy over the next month with trips to Ukraine and Azerbaijan on the itinerary, to face Vorskla and Qarabag respectively.
In the Premier League, the fixtures should pose few problems to a title-chasing team – but that is almost certainly not Arsenal. Newcastle away will be difficult, as will Everton at home. A flying Watford will be no pushovers, either.
If there is still drama and misery at Old Trafford following this run of fixtures then there really are problems ahead for Jose Mourinho.
Watford will provide a stern test first up, but after the trip to Vicarage Road it all appears to be relatively straightforward.
Wolves and Newcastle come to Manchester, along with Derby in the League Cup.
Valencia’s Champions League visit has the potential for issues, although a trip to Young Boys should result in three points.