Living near to a noisy road or an airport triples your risk of a heart attack or stroke, research suggests.
Scientists warned the boosted odds also exist for non-smokers and people who don’t have diabetes – who already face a heightened risk.
Exposure to environmental noise drives a brain region involved in stress response, Massachusetts General Hospital experts say.
This then promotes blood vessel inflammation, which can lead to cardiovascular problems, such as heart attacks and strokes.
Researchers led by Dr Azar Radfar used 499 people for the study. Participants had an average age of 56 years old in the study.
The findings were presented at the American Heart Association’s Scientific Sessions conference in Chicago today.
None of the participants had cardiovascular illness or cancer. They all underwent simultaneous PET and CT scans of their brain and blood vessels.
Using those images, the scientists assessed the activity of the amygdala – an area of the brain involved in stress regulation and emotional responses.
To gauge noise exposure, the researchers used participants’ home addresses and derived noise level estimates from the Department of Transportation’s Aviation and Highway Noise Map.
To capture cardiovascular risk, the researchers examined the participants’ medical records following the initial imaging studies.
Of the 499 participants, 40 experienced a cardiovascular event, such as a heart attack or stroke, in the five years following the initial testing.
People with the highest levels of noise exposure had higher levels of amygdala activity and more inflammation in their arteries.
Their risk of suffering a heart attack or stroke was greater than three-fold, compared with people who had lower levels of noise exposure.
That risk remained elevated even after the researchers accounted for other risk factors, including air pollution, high cholesterol, smoking and diabetes.
Additional analysis revealed that high levels of amygdalar activity appears to unleash a pathway that fuels cardiac risk by driving blood vessel inflammation, a well-known risk factor for cardiovascular disease.
‘A growing body of research reveals an association between ambient noise and cardiovascular disease, said Dr Radfar.
‘But the physiological mechanisms behind it have remained unclear.
‘We believe our findings offer an important insight into the biology behind this phenomenon.’
The results of the study offer much-needed insight into the biological mechanisms of the well-known, but poorly understood, interplay between cardiovascular disease and chronic noise exposure, researchers said.
They caution that more research is needed to determine whether reduction in noise exposure could meaningfully lower cardiovascular risk and reduce the number of cardiovascular events on a population-wide scale.
In the meantime, however, the new findings should propel clinicians to consider chronic exposure to high levels of ambient noise as an independent risk factor for cardiovascular disease.
‘Patients and their physicians should consider chronic noise exposure when assessing cardiovascular risk and may wish to take steps to minimize or mitigate such chronic exposure,’ Dr Radfar said.
Last month, research also linked traffic noise pollution to a higher risk of depression. Researchers warned that being regularly exposed to more than 65 decibels, which is quieter than a lorry, can increase a persons risk by two thirds.