Man allergic to ejaculating suffers anxiety, fatigue, muscle weakness and mental fogginess


A man who dreaded ejaculating has been cured of his bizarre disorder after getting hormone replacement therapy.

The unidentified 25-year-old, of Massachusetts, hated climaxing because it caused him anxiety, fatigue, muscle weakness and brain fog. 

The symptoms were so debilitating he abstained from masturbating and attempted to avoid ejaculation when having sex with partners.

He was diagnosed with post-orgasm illness syndrome (POIS). Symptoms lasted up to two weeks and could strike immediately or be delayed by two to three days. 

But he has since been cured after getting injections of a hormone that boosted his levels of testosterone. 

During his post-orgasm blues he avoided social contact and couldn’t bear to go into work or university.

On average, he allowed himself to orgasm just once every eight to twelve weeks, doctors who treated him revealed. 

The patient revealed he had been suffering from POIS condition since going through puberty at the age of 16.

POIS is believed to be caused by men having an allergy to their own semen, either through contact or due to a rush of hormones released during climax.

And though the exact cause is unclear, researchers speculate it may be affecting far more men who don’t report their symptoms.

The condition was first reported in 2002 but since then about 50 cases have been documented.

All the men had a range of flu-like and allergy symptoms – such as runny noses and burning eyes – after ejaculating. 

The most recent tale was revealed in Urology Case Reports by medics from Men’s Health Boston in Massachusetts.

They said the man had seen several doctors who gave him antidepressants and anti-anxiety medication.

He also carried out hours of his own online research, trying various diets, as well as supplements and antihistamines – but to no avail. 

When he was finally referred to Men’s Health, urologists discovered his testosterone levels were low.

His body was sluggish at replenishing the sex hormone whenever he ejaculated, the medics revealed. 

He was prescribed human chorionic gonadotropin (hCG) replacement therapy, which he injected three times a week.

HCG is sometimes called ‘the pregnancy hormone’ because of its important role in maintaining pregnancy.

But in men, injections of the hormone can stimulate the testicles to produce more testosterone. 

At six-week follow-up, his symptoms had been cured completely. He ejaculated more frequently and experienced no weakness, anxiety, brain fog, or malaise afterwards. 

He noted improved mood, overall energy, and libido. Blood tests showed robust levels of total testosterone.

He reported this was the first time since he was 16 that he could experience orgasm without negative physical or emotional consequences afterwards. 

At six months of follow-up he continued hCG treatment, was happy, and masturbated several times per month. 

He still described mild POIS symptoms immediately following orgasm, but these resolved within 12 hours and were not bothersome. 

Researchers at the University of Utrecht in the Netherlands claimed POIS may be caused by an allergy to semen almost a decade ago. 

An analysis of 45 men who had been diagnosed with the illness revealed none of them felt ill when they masturbated without ejaculating.

Most of the men agreed to undergo a standard skin-prick allergy test using a diluted form of their own semen. 

Of those, 88 per cent, had a positive skin reaction which indicated an auto-immune response, or allergic reaction.


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